Split doses of Methotrexate in patients with moderate to severe Psoriasis.

white dots in the ocular fundus which appear after several years of age,3 and their occurrence strongly suggests SLS.4 Macrocephaly is not a characteristic or common finding in SLS. Mutation analysis of the ALDH3A2 gene is a highly sensitive method of confirming the diagnosis of SLS.4 More than 90 pathogenic variants of ALDH3A2 have been identified to date.1 The diagnosis of SLS can be confirmed by measurement of enzyme activity in cultured skin fibroblasts or leukocytes. There is no permanent cure for SLS and no specific therapy, so that a multidisciplinary approach is necessary.3 In conclusion, we report a new case of SLS caused by two novel mutations, supporting the rich mutational heterogeneity associated with this syndrome. High index of suspicion is necessary for the diagnosis of SLS, so that in a neonate or infant with congenital ichthyosis and neurological symptoms we must rule out this neurocutaneous disorder.